Vascular

Branching

155

stress and shear rate have been shown to be important, as well as local

turbulence and unsteady flow. In addition local disturbed flow patterns,

recirculation zones, long particle residence times have been suggested to

play significant roles in the onset and development of atherosclerosis.

Fig.

5.2.8:

Illustration

of

the distribution of atherosclerotic occlusive disease in humans.

From DeBakey et al.

(1985).